Alligator Bioscience has published biomarker data from the phase Ib/II study OPTIMIZE-1 in Cell Report MedicineThe study evaluates the CD40 agonist mitazalimab in combination with mFOLFIRINOX in metastatic pancreatic cancer. Results showed a 42,1 percent objective response rate and a median survival of 14,9 months. A specific gene signature linked to the mechanism of action of mitazalimab was observed in patients with better treatment response. Data support continued development towards phase III.
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Published October 8, 2025
Alligator publishes biomarker data from OPTIMIZE-1
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